Research and Studies
There is growing scientific evidence regarding the potential benefits of using hyperbaric oxygen therapy (HBOT) in a wide range of conditions. Hyperbaric Oxygen Therapy is an emerging therapy, and so research into its efficacy is ongoing.
Please note that the information on this website, including listed medical research papers below, texts, graphics, images or other material, is for informational purposes only and may not be appropriate or applicable for your individual circumstances. This website does not provide medical advice and is not a substitute for consultation with a healthcare professional. You should seek medical advice from a qualified healthcare professional for any questions regarding your condition. This website should not be used for medical diagnosis or treatment.
At NUMA, we aim to keep up to date with the latest research and regularly attend global conferences with the world’s leading experts. We closely follow innovative developments in the hyperbaric oxygen field to provide the best care for our patients. We strive to maintain active records of research on Hyperbaric Oxygen Therapy. For each condition listed below, you can access the applicable research by clicking the links. Please note that although many of these conditions have undergone significant research, the use of HBOT is not authorised other than FDA/UHMS approved conditions.
We are continually updating our records as new research becomes available, so please tune in for updates.
Sports Injuries
- Effects of Hyperbaric Oxygen and Platelet Derived Growth Factor on Medial Collateral Ligament Fibroblasts
- Effects of Hyperbaric Oxygen on Proliferation and Differentiation of Osteoblasts from Human Alveolar Bone
Hamstring Injuries
Spinal Cord Injuries
- The Effect of Hyperbaric Oxygen on Neuroregeneration Following Acute Thoracic Spinal Cord Injury
- Attenuating Experimental Spinal Cord Injury by Hyperbaric Oxygen: Stimulating Production of Vasculoendothiel and Glial Cell Line-Derived Neurotrophic Growth Factors and Interleukin-10
- Hyperbaric Oxygen Therapy Improves Local Microenvironment After Spinal Cord Injury
- Effect of Hyperbaric Oxygen on GDNF Expression and Apoptosis in Spinal Cord Injury
- Hyperbaric oxygen in the treatment of patients with cerebral stroke, brain trauma, and neurologic disease
- Hyperbaric Oxygen Therapy Can Improve Post Concussion Syndrome Years after Mild Traumatic Brain Injury – Randomized Prospective Trial
- Hyperbaric oxygen may induce angiogenesis in patients suffering from prolonged post-concussion syndrome due to traumatic brain injury
- Effect of Hyperbaric Oxygen Therapy on Chronic Neurocognitive Deficits of Post-Traumatic Brain Injury Patients: Retrospective Analysis
- A Phase I Study of Low-Pressure Hyperbaric Oxygen Therapy for Blast-Induced Post-Concussion Syndrome and Post-Traumatic Stress Disorder
- Hyperbaric Oxygen Therapy and SPECT Brain Imaging in the Treatment of Chronic Brain Injury
- Low Pressure Hyperbaric Oxygen Therapy and SPECT Brain Imaging in the Treatment of Blast-Induced Chronic Traumatic Brain Injury (Post-Concussion Syndrome) and Post Traumatic Stress Disorder: A Case Report
- Case report: Treatment of Mild Traumatic Brain Injury with Hyperbaric Oxygen
- Hyperbaric oxygen: B-level evidence in mild traumatic brain injury clinical trials
Dementia / Cognitive impairment
- Hyperbaric oxygen therapy improves cognitive functioning after brain injury
- Effect of hyperbaric oxygen therapy on chronic neurocognitive deficits of post-traumatic brain injury patients: retrospective analysis
- Hyperbaric oxygen therapy for Alzheimer’s dementia with positron emission tomography imaging: a case report
Fibromyalgia / ME / Chronic Fatigue
- The efficacy of Hyperbaric Oxygen Therapy in the management of Chronic Fatigue Syndrome
- A New Treatment Modality for Fibromyalgia Syndrome: Hyperbaric Oxygen Therapy
- Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial
Chronic Pain
- Effectiveness of Hyperbaric Oxygen Therapy in the Treatment of Complex Regional Pain Syndrome
- Hyperbaric oxygenation in peripheral nerve repair and regeneration
- A Novel Treatment Modality for Myofascial Pain Syndrome: Hyperbaric Oxygen Therapy
- Effectiveness of Hyperbaric Oxygen Therapy in the Treatment of Complex Regional Pain Syndrome
- Successful Treatment of Lower Limb Complex Regional Pain Syndrome following Three Weeks of Hyperbaric Oxygen Therapy
- The Severity Spectrum in Persistent Complex Regional Pain Syndrome (CRPS), Palliation with Ongoing Hyperbaric Oxygen Therapy (HBOT), and the Role of Serial Photo-Documentation (P6.271)
- Hyperbaric oxygen and the reflex sympathetic dystrophy syndrome: a case report
- Successful Treatment of Lower Limb Complex Regional Pain Syndrome following Three Weeks of Hyperbaric Oxygen Therapy
Sudden Sensorineural Hearing Loss
- Addition of Hyperbaric Oxygen Therapy vs Medical Therapy Alone for Idiopathic Sudden Sensorineural Hearing Loss
- Sudden hearing loss and early hyperbaric oxygen therapy: A preliminary study
- Should hyperbaric oxygen be added to treatment in idiopathic sudden sensorineural hearing loss?
- Hyperbaric oxygen as a method of therapy of sudden sensorineural hearing loss
- Prognostic effect of hyperbaric oxygen therapy starting time for sudden sensorineural hearing loss
- Clinical Practice Guideline: Sudden Hearing Loss
- Hyperbaric oxygen therapy in idiopathic sudden sensorineural hearing loss (ISSNHL) in association with combined treatment
- Addition of Hyperbaric Oxygen Therapy vs Medical Therapy Alone for Idiopathic Sudden Sensorineural Hearing Loss
Inflammatory Bowel Disease/ Crohn’s Disease / Ulcerative Colitis
- Hyperbaric Oxygen for Perianal Crohn’s Disease
- Hyperbaric Oxygen Therapy for Severe Ulcerative Colitis
- Hyperbaric oxygen treatment for inflammatory bowel disease: a systematic review and analysis
- Systematic review: the safety and efficacy of hyperbaric oxygen therapy for inflammatory bowel disease
Stroke
- Hyperbaric oxygen therapy: A new look on treating stroke and traumatic brain injury
- Hyperbaric Oxygen Induces Late Neuroplasticity in Post Stroke Patients
- Oxygen Therapy in Stroke: Past, Present, and Future
- Rationale of Hyperbaric Oxygenation in Cerebral Vascular Insult
- Hyperbaric Oxygen Induces Late Neuroplasticity in Post Stroke Patients
Lyme Disease
- Hyperbaric oxygen therapy as an effective adjunctive treatment for chronic Lyme disease
- The efficacy of Hyperbaric Oxygen Therapy in the management of Chronic Fatigue Syndrome
- A New Treatment Modality for Fibromyalgia Syndrome: Hyperbaric Oxygen Therapy
- Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial
Pre-Operative Conditioning and Post Surgical Recovery / Wound Healing
- Hyperbaric Oxygen Preconditioning Can Reduce Post-abdominoplasty Complications: A Retrospective Cohort Stud
- Hyperbaric Oxygen Therapy: Solution for Difficult to Heal Wounds – Systematic Review
- Hyperbaric Oxygen Therapy for Wound Healing and Limb Salvage: a Systematic Review
- Hyperbaric Oxygen Therapy with Topical Negative Pressure: an Alternative Treatment for the Refractory Sternal Wound Infection
- Hyperbaric Oxygen Therapy for Non-Healing Vasculitic Ulcers
- Hyperbaric Oxygen Therapy as an Elective Treatment
- Oxygen in Wound Healing—More than a Nutrient
- In vivo effect of hyperbaric oxygen on wound angiogenesis and epithelialization
- Hyperbaric Oxygen Preconditioning Can Reduce Post-abdominoplasty Complications: A Retrospective Cohort Study
- Ischemic scleroderma wounds successfully treated with Hyperbaric Oxygen Therapy
- Effect of HBOT on nerve regeneration in early diabetes
Interstitial Cystitis
- van Ophoven A, et al. Hyperbaric oxygen for the treatment of interstitial cystitis: long-term results of a prospective pilot study. Eur Urol. 2004 Jul;46(1):108-13.
- van Ophoven A, et al. Safety and efficacy of hyperbaric oxygen therapy for the treatment of interstitial cystitis: a randomized, sham controlled, double-blind trial. J Urol. 2006 Oct;176(4 Pt 1):1442-6.
- Tanaka T, et al. Hyperbaric oxygen therapy for interstitial cystitis resistant to conventional treatments. Int J Urol. 2007 Jun;14(6):563-5.
- Tanaka T, et al. Hyperbaric oxygen therapy for painful bladder syndrome/interstitial cystitis resistant to conventional treatments: long-term results of a case series in Japan. BMC Urol. 2011 May 24;11:11.
- Gallego-Vilar D, et al. Maintenance of the response to dimethyl sulfoxide treatment using hyperbaric oxygen in interstitial cysti- tis/painful bladder syndrome: a prospective, randomized, comparative study.Urol Int. 2013;90(4):411-6.
- Wenzler DL, et al. Treatment of ulcerative compared to non-ulcerative interstitial cystitis with hyperbaric oxygen: a pilot study.
Video podcasts
- HBOT to Overcome Chronic Fatigue with Dr. Scott Sherr MD and Ari Whitten, *Dr. Sherr is a board-certified internal medicine physician who provides worldwide HBOT consultations, education, and advocacy telemedicine practice.
- The Brain Therapeutic Effects of Hyperbaric Oxygen by Professor Shai Efrati
Anti-Aging/ Rejuvenation
Podcasts/ Videos:
